Semax Nasal Spray

Adrenocorticotropic hormone has a short internal stretch, residues 4 through 7: Met-Glu-His-Phe. Researchers at Russia's Institute of Molecular Genetics trimmed that stretch from ACTH(4-10) and stuck a Pro-Gly-Pro tail on the end. The tail slows carboxypeptidase attack. The same tail later went onto Selank, which is built from a different parent peptide.^[2]

Seven residues. A free carboxylic acid at the C-terminus. That is the molecule in this bottle.

It is the same heptapeptide as the lyophilized Semax vials. The container is different. This SKU is a clear nasal solution, one 10 mg bottle, $79. No 5-pack. No 10-pack. No second strength. The specs table should read as a spray, not a white lyophilized puck.

N-Acetyl Semax and N-Acetyl Semax Amidate add an acetyl group at the N-terminus, an amide in place of the C-terminal acid, or both. Other vendors often sell those as a 30 mg analog. Tetrava Labs carries a separately specified acetylated analog under Adamax. Read the sequence on the lot COA before treating any Semax-family listing as this one.

The registered Russian product is an intranasal solution. Once a peptide has a nasal drug product, later papers tend to keep using that route.

Dolotov's 2006 hippocampal BDNF paper used a single intranasal dose. Romanova's cortical-infarct study dosed rats in the nose for six days. Polunin's optic-nerve trial compared intranasal drops with endonasal electrophoresis.^[3][4][11] A second 2006 Dolotov paper, in Journal of Neurochemistry, also used the nose: 50 and 250 micrograms per kilogram, then BDNF protein in basal forebrain at three hours.^[13]

Labs pick the olfactory and trigeminal routes when they want material near CNS tissue without a systemic injection. That choice belongs to the protocol. It does not turn Tetrava's 10 mg research spray into a pharmacokinetic map, and it does not make a spray bottle the right tool for an in-vitro enzyme plate.

"Semax nasal spray benefits" usually wants a human outcome. The papers have endpoints: BDNF protein, trkB phosphorylation, infarct volume, conditioned avoidance, optic-nerve scores. Those are study readouts. They are not a result from this research bottle used on a person.

The mechanism thread that gets cited most is gene expression, not a single named receptor. Shadrina 2010 compared BDNF and NGF mRNA timing across rat hippocampus, frontal cortex, and retina. The transcripts moved on different clocks. Hippocampus responded first.^[5] BDNF is a neuron-survival and synaptic-plasticity readout in those models. NGF is the cholinergic-neuron one.

The same year as the hippocampal fold-change paper, Dolotov's group asked a more basic question: does the basal forebrain even have a binding site? Tritium-labelled Semax bound rat basal-forebrain membranes in a time-dependent, specific, reversible way. Binding needed calcium ions. They reported a KD of 2.4 nM (SEM 1.0) and a Bmax of 33.5 fmol/mg protein (SEM 7.9).^[13] Then they put the peptide in the nose at 50 and 250 micrograms per kilogram. BDNF protein was up at three hours in basal forebrain. Cerebellum did not move. The authors had already seen Semax raise BDNF synthesis in basal-forebrain astrocytes in culture. This experiment asked whether the intact rat would show it after an intranasal dose.

Search results for N-Acetyl Semax nasal spray, Semax amidate, and Adamax sit next to unmodified Semax because the names share a stem. Acetylation and C-terminal amidation change how peptidases clip the chain. None of the papers cited on this page is a head-to-head of N-Acetyl Semax against this unmodified spray.

If the protocol specifies the acetylated analog, use Adamax and that page's identity data. If it specifies native Semax as a finished spray, this is the listing. A 30 mg amidate vial from another vendor is not this 10 mg bottle.

"Semax nasal spray vs injection which is better" treats route as a personal ranking. In the literature, route follows the question. The registered product is nasal. Dolotov and Romanova used the nose because that is how the Russian drug is given.

Injection from a reconstituted lyophilized vial is a different setup: known volume, known concentration, no spray-orifice variability. Pick the format the protocol names. This SKU is the finished spray. The powder is the lyophilized Semax vial.

You don't, not from this listing. This is a finished spray. It does not need bacteriostatic water, a milliliter chart, or a pump bottle you fill at the bench.

How to make Semax nasal spray, how to mix it, how to reconstitute Semax 10 mg for a spray, and how to make Semax and Selank nasal spray are compounding recipes. This page will not publish one. If the protocol needs a dry reagent, buy the lyophilized vial and write diluent, concentration, and device into the laboratory SOP.

Dolotov, Karpenko, Inozemtseva and colleagues gave rats a single 50 micrograms per kilogram intranasal dose of Semax and then measured the hippocampal BDNF/trkB system. BDNF protein rose to a maximum of 1.4-fold. TrkB tyrosine phosphorylation rose 1.6-fold. Exon III BDNF mRNA rose 3-fold. TrkB mRNA rose 2-fold. The same animals showed more conditioned avoidance reactions than controls.^[3]

Use this paper when the assay question is a single intranasal dose and hippocampal protein plus phosphorylation. Use Shadrina 2010 when the question is BDNF and NGF mRNA on different clocks in hippocampus, cortex, and retina.^[5] Use the Journal of Neurochemistry paper when the question is a basal-forebrain binding site and a three-hour BDNF protein rise that did not appear in cerebellum.^[13]

Those are rat protocols with fixed timepoints. They are not a timer for when a person would feel something.

Romanova 2006 used photochemically induced prefrontal infarction in rats. Six days of intranasal Semax reduced infarct volume and improved passive-avoidance performance against untreated controls.^[4]

Two later papers went into the same ischemia-reperfusion biology without turning this spray into a drug. Filippenkov 2020 counted 394 differentially expressed genes after transient middle-cerebral-artery occlusion. Inflammation-related transcripts went down relative to saline. Neurotransmission-related transcripts went up.^[6] Sudarkina 2021 measured protein instead of RNA. Active CREB went up. MMP-9, c-Fos, and active JNK went down.^[7] Transcriptome, then proteome. Rodent. Not a human dose-response for this bottle.

A 2000 Vestnik Oftalmologii trial tested Semax in vascular, toxic-allergic, and inflammatory optic-nerve disease, including partial optic-nerve atrophy. Three groups: intranasal drops, endonasal electrophoresis, untreated control. Both treated arms were tied to better visual acuity, a wider visual field, better electrical conductivity through the optic nerve, and improved color vision relative to the control group.^[11] One Russian trial. No independent Western replication.

Gusev 2018 is the other human line most often cited, a series on patients treated at different stages of ischemic stroke. PubMed indexes it as a clinical trial. Same single-health-system limit.^[12]

Semax nasal spray dosage, dosage instructions, how to take it, how to use it, and how much to use are human-use questions. The listing is Research Use Only. There is no administration video, no spray-count chart, and no "how should I take this" answer here.

Laboratory handling is ordinary chemical-hygiene work. Keep the bottle sealed until use. Store it at 2-8°C. Record lot, operator, time, and any temperature excursion in the ELN. Prime a research spray device only if the SOP says to. Do not share applicators across operators or study arms.

Selank and Semax share a Moscow lab and the Pro-Gly-Pro tail. Semax is built from an ACTH fragment. Its literature is neurotrophin expression, ischemia models, and stroke recovery. Selank is built from tuftsin. The published work around it is anxiolytic scores, enkephalin metabolism, and GABAergic transcripts.^[2] They are not interchangeable.

No published trial reviewed for this page tests Semax and Selank administered together. There is no combined dosage chart and no instruction for how to make Semax Selank nasal spray. Tetrava Labs sells this Semax spray and a finished Selank nasal spray as two bottles, plus lyophilized Semax and Selank vials. If a protocol needs both molecules, they stay separate reagents.

This page will not publish a human side-effect list for a Research Use Only spray. The animal papers report study endpoints, not a consumer adverse-event table. Forum posts about headache, congestion, or mood are uncontrolled reports.

The FDA has never approved Semax in any form. In July 2026 the Pharmacy Compounding Advisory Committee reviewed seven peptide bulk substances nominated for the Section 503A Bulks List. Semax was on that list. Selank was not.^[9] An open rulemaking docket is not an approval. It does not make this catalog item a compounded medicine.

Russia's 1994 registration is a low-concentration intranasal solution for cognitive and optic-nerve indications, with a later stroke registration.^[8] Tetrava Labs does not sell that medicine. UK and Australia orders depend on destination rules that change. Check shipping restrictions before you order.

Store Semax nasal spray at 2-8°C, protected from light, and do not freeze it. Lyophilized Semax is held dry at -20°C. Mixing those two rules is the usual receiving error. Adamax is a third SKU with its own storage line. Do not file it as this spray.

How long the unopened bottle is dated for is on the lot COA: manufacture and expiry for the batch in hand. This page will not invent a universal shelf life, and it will not give a household "how long does it last after opening" window. In-use time belongs in the SOP.

No pharmacokinetic study reviewed here publishes a plasma half-life for intact Semax the way a drug label would. What is published is a breakdown map. Zolotarev 2006, using isotopically labeled Semax, found rat basal-forebrain plasma membranes and cell cultures clip Met-Glu off the N-terminus and Gly-Pro off the C-terminus. Pentapeptide fragments were the main byproduct. Glial and neuronal cells produced slightly different fragment patterns from the same starting peptide.^[10]

That map is about how the chain gets cut in tissue culture. It is not "how long until it works." Dolotov's hippocampal paper used a single rat dose and a BDNF readout. The basal-forebrain paper used a three-hour protein timepoint. Those clocks belong to the experiments.

You can buy Semax nasal spray online from Tetrava Labs on this page: 10 mg, one bottle, $79. Semax nasal spray for sale here means that SKU, not a 5-pack and not a mixed Selank bottle. Shipping is free on all orders. Checkout is card (Peptide Pay) or crypto. ACH is not a listed payment method.

Where to buy Semax nasal spray in the UK, Australia, or elsewhere depends on destination rules. Check shipping restrictions before you order. Tetrava Labs does not tell you how any country classifies this peptide.

"Best place to buy Semax nasal spray 2026" is a slogan unless the listing can show paperwork. Same test for the Semax-plus-Selank version of that query. Tetrava does not sell a combo spray. A reputable vendor for this format publishes a lot-linked COA, states that the bottle is unmodified Semax rather than N-Acetyl Semax, and states 2-8°C storage.

• Lot match: the COA batch number has to match the bottle in hand, not a PDF reused across products. File it from the COA library against the label.
• Identity: HPLC purity plus sequence or mass confirmation for Met-Glu-His-Phe-Pro-Gly-Pro, CAS 80714-61-0, CID 9811102, formula C37H51N9O10S, MW 813.93.
• Format and storage: finished nasal spray bottle, 2-8°C, do not freeze. A -20°C lyophilized listing is a different SKU. Adamax is a different analog.
• Claims: a vendor calling itself the best place to buy Semax nasal spray without a lot-linked COA is selling a sentence.